A REVIEW ON DIFLUOROMETHYLATION OF ARYL AND HETEROARYL COMPOUNDS
DOI:
https://doi.org/10.59367/jpcgn797Abstract
The difluoro methylated aryl andheteroaryl compounds are of immense importance in agrochemical and pharmaceutical industry owing to the various properties of difluoro methyl group (CF2H) like weakly acidic nature and capability of hydrogen-bonding interactions that improve the binding selectivity of biologically active compounds and it can act as a more-lipophilic isostere of carbinol, thiol, hydroxamic acid or amide groups.The transition metals in difluoro methylation reactions play various roles, including stabilizing the difluoro methyl anion (as difluoro methyl carriers), promoting the formation of difluoro methyl free radicals (such as transition-metal photo redox catalysts) and facilitating the formation of HF2C-C and HF2C-X bonds (through the reductive elimination of difluoro methyl-metal complexes).This review paper discuss about the various methods that have been reported for difluoro methylation reactions using various transition metals like, copper, palladium, palladium/silver (bimetallic catalyst system), silver, nickel, palladium with platinum, Iridium photo catalyst etc.
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