OXIDATIVE DEGRADATION OF CIPROFLOXACIN BY WATER SOLUBLE COLLOIDAL MNO2 IN MICELLAR MEDIA

Neelam Sen

doi:10.59367/n2n02r88

Authors

Neelam Sen Dau Uttam Sao Govt. College Machanuur Durg 491221, Chhattisgarh, India

DOI:

https://doi.org/10.59367/n2n02r88

Abstract

This work aimed at demonstrating the oxidative degradation of fluoroquinolone antimicrobial ciprofloxacin (CIP)by water soluble colloidal MnO₂in acidic medium has been studied spectrophotometrically in the presence of micelles at 298K. The rate of reaction was found first order with respect to [MnO₂], [PCM] and [H₂SO₄]. The rate constant decreased with decreasing in dielectric constant of the medium.Ionic strength did not influence rate of reaction. CTAB enhanced the reaction rate i.e. with a progressive increase in [CTAB],the catalytic role of CTAB has been explained by Menger- Portnoy model and Piszkiewickz model. Oxidation product was identified and thermodynamic activation parameters have been calculated with the help of Arrhenius equation.

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